This presentation explores the time-honored role of bacteria, fungi, and plants in evolution, adaptation, succession, and remediation. Let's examine the connections between Traditional Ecological Knowledge (TEK) and nature-based remediation, recognizing the value of both culture and science. We will build bridges to how natural remediation practices support self-determination, environmental stewardship, and economic development. Topics include early bioremediation strategies, constraints, recent advancements, and practical, culturally sensitive applications that balance modern technologies with the Indigenous lens. We will also explore broader social, ecological, and economic opportunities-such as Tribal Response Programs (TRP's), job training, and entrepreneurship-and how culturally grounded-decision making can guide land restoration, regeneration and remediation efforts. This session invites dialogue around honoring Indigenous relationships with the land while advancing practical sovereign solutions for environmental recovery.